A new molecule discovered by a team led by Professor Sathees C. Raghavan, of the biochemistry department at IISc might hold the key to curing cancer.
Sathees C Raghavan, associate professor with IISc?s biochemistry department, and his associates identified a novel small molecule, SCR7, named after its discoverer. It inhibits DNA double-strand break (DSB) repair. By inhibiting DNA repair, the cancer cells are disintegrated.
The molecular inhibitor, SCR7, which has been successful in eradicating cancer cells on laboratory mice, will now be pushed for clinical trials. If successful, it could bring about a major breakthrough in annihilating 90% of the known cancer cells, except for lymphoma and leukemia, in humans.
?It is the first DNA inhibitor focusing on double strand break repair?, explained Professor Raghavan. ?And what it does, in layman?s terms, is prevent the cancer cell from repairing double strand DNA repair, which will then kill the cell itself. This happens when it binds with the enzyme ligase IV, a combination which will block the repair pathways of the DNA?.
These findings were published in CELL.It is only the third paper in India to be published by CELL.
The research is a joint effort by KLE University?s College of Pharmacy, Bengaluru, Institute of Bioinformatics and Applied Biotechnology, Bengaluru, and Advanced Centre for Treatment, Research and Education in Cancer, Navi Mumbai.
Sources:
http://www.deccanchronicle.com/
http://timesofindia.indiatimes.com/
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Source: http://iseeindia.com/2013/01/03/indian-scientist-discovers-anti-cancer-molecule/
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